The scope of the Tranquilizer Rifle can be used to zoom in and hit targets from a far distance. Shooting Hunters in the body will stun them for a short while, and a shot to the head will cause them to pass out for a longer time before waking up again. The weapon itself cannot kill an enemy, but will allow the player to hit them while they are down with another weapon or with Fists.
If the player is shot, a small amount of health will be lost and the screen will turn blurred for a short time.
The Tranquilizer Rifle can only be found at Carcer City Zoo and is used by the Wardogs. Starkweather claims it was the Wardogs' own idea to use them to make it easier to kill Cash. Many Wardogs that use them, stand on higher ground to get a good view of the surroundings to sight him.
Missions in Manhunt: