Head of "The Pickman Project". The Project is named after him. After the government cut funding off for his work due to its inhumane methods, he went underground and continued his research. He is a heartless and cruel person, caring little about the suffering that his experiments cause on his test subjects. He created the "Pickman Bridge," the final product of the Project, which would implant a separate personality with an expertise in killing into an unknowing subject. Using codes hidden in the broadcasts of a television station that the Project runs, the subject's separate personality would trigger and perform their duty, afterward reverting back to the subject's real personality. Danny was the first successful recipient of the Pickman Bridge, but after the bridge malfunctioned and Leo proved to be uncontrollable, Pickman ordered his capture. After Leo killed Danny's wife, the Project finally caught him. Daniel was then locked away into the Dixmor Asylum for six years while Pickman and Dr. Whyte worked to undo the damage. After escaping the asylum and killing off the Project's hunters, Daniel breaks into Dr. Pickman's lair only to be put in a sedative state when Pickman recites a phrase from the Shakespearean play The Tempest over the intercom. Danny eventually regains consciousness and finds Pickman in the Project Laboratories auditorium. When Pickman is finally confronted, Danny sedates him with a tranquilizer gun, as he is needed alive.
Pickman wakes up strapped to a wheelchair, and Leo demands that he should remove the bridge so he can be free, not realizing that if this were to happen, Leo would die, as he is not the dominant personality. The doctor attempts to initiate a hypnotic state a second time, but Leo goes insane and manages to grab a scalpel and stab him several times in the heart before succumbing.
- Personality Clash (Revived, Killed)
- Dr. Pickman may be a reference to a character in one of H.P Lovecraft's short stories entitled "The Pickmans Model".